EpiHealth - Cohorts of Sweden
Short description of background, aims, hosting institution:
EpiHealth is a large population-based study with a prospective design, that aims to build a national resource in the form of a multicenter longitudinal cohort study. It will investigate the interaction between genes and life-style factors regarding the development of common diseases seen in the elderly in Swedish men and women between the ages of 45 and 75 years.
The EpiHealth cohort study is a collaboration project between Uppsala and Lund Universities that was evaluated in 2009.
EpiHealth consists of three parts -a web-based baseline questionnaire, physical tests and biological sampling at a test centre, and follow-up through official Swedish registers regarding future diseases. The baseline questionnaire provides information about the participants' medical history and life-style and is divided into fifteen sections such as family structure, education, and physical activity. The baseline questionnaire can be completed at home by logging in to a personal webpage at www.epihealth.se. At the EpiHealth Test Centre, physical measurements and blood samples are collected to provide baseline data, such as the participants' cardiovascular status, lung and cognitive function. The EpiHealth database will be merged with the unique Swedish registries regarding health care, as specified below.
A follow-up of the cohort, for example each 5th year, following the baseline investigation regarding information that could be obtained by the web-based questionnaire is planned. If economically feasible, a follow-up test centre visit, for example each 10th year, is planned.
There is a close collaboration with the LifeGene project in that we share the same IT-based data structure for collecting life-style information and biobanking.
The study started with the opening of a test centre in Uppsala April 26th 2011. The second test centre opened in Jan 11th 2012 in Malmö.
Main focus of research: impact of life-style factors and biochemical and genetic markers on common diseases, especially coronary heart disease.
Approximate number of probands: 2013: 25,000, final: 300,000.
Types and number of biosamples available: DNA, serum, plasma; final: 1,4 million.
PI of the Uppsala part of the study is Professor Lars Lind, lars.lind[at]medsci.uu.se.
PI of the Lund/Malmö part of the project is Professor Sölve Elmståhl, solve.elmstahl[at]med.lu.se.
Contact for BBMRI-LPC:
Department of Medical Sciences & Uppsala Clinical Research Center
Entrance 40, 5th floor, Uppsala University Hospital
Baseline variables: https://www.epihealth.se/For-scientists/Research-Application-/