LifeGene - Cohorts of Sweden
Short description of background, aims, hosting institution:
The LifeGene study is a national collaborative project designed to build up a resource for research in all medical disciplines, enabling new and groundbreaking research on the relationships among heredity, environment and lifestyle. The study will include studying half a million Swedes with the aim of creating new tools to prevent, diagnose, and treat our most common diseases.
LifeGene is designed both as a prospective cohort study and an infrastructure with repeated contacts of study participants approximately every 5 years. Index persons aged 18-45 years old will be recruited and invited to include their household members (partner and any children). A comprehensive questionnaire addressing cutting-edge research questions will be administered through the web with short follow-ups annually. Biosamples and physical measurements will also be collected at baseline, and re-administered every 5 years thereafter. Event-based sampling will be a key feature of LifeGene. The household-based design will give the opportunity to involve young couples prior to and during pregnancy, allowing for the first study of children born into cohort with complete pre- and perinatal data from both the mother and father. Questions and sampling schemes will be tailored to the participants' age and life events. The target of LifeGene is to follow study participants longitudinally for at least 20 years.
LifeGene is coordinated from Karolinska Institutet. The administrative home of LifeGene is the Department of Medical Epidemiology and Biostatistics (MEB) at Karolinska Institutet.
Main focus of research: impact of genes, environment and way of life on health.
Approximate number of probands: final: 250.000.
Types and number of biosamples available: plasma, serum, urine, final: 10 million samples.
Phone +46-8-524 874 18
Nobels väg 12A
SE-171 65 Solna
Contact for BBMRI-LPC:
Department of Medical Epidemiology and Biostatistics
PO Box 281
SE-171 77 Stockholm
Information on resources (pdf): www.lifegene.se/PageFiles/136/Lifegene%20resource%202011-09-30%20version%201.0.pdf