Short description of background, aims, hosting institution:
The MORGAM (MOnica Risk, Genetics, Archiving and Monograph) Project is a multinational collaborative study exploring the relationships between the development of cardiovascular diseases, their classic and genetic risk factors and biomarkers. This is done through follow-up of cohorts examined in the MONICA risk factor surveys and other studies.
MORGAM has harmonized data from prospective cohorts from 21 participating centres in 12 countries in the MORGAM Data Centre at the National Institute for Health and Welfare of Finland (THL). Additional cohorts are being harmonized. The Centres have shared DNA for joint genotyping and stored serum and plasma for joint measurement of biomarkers.
The MORGAM Project subsequently became part of GenomEUtwin (a Network of Excellence for Genomics in Europe, FP5) and ENGAGE (European Network in Genetic And Genomic Epidemiology, FP7), and currently participates in CHANCES (Consortium on Health and Ageing: Network of Cohorts in Europe and the United States, FP7) and BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe, FP7).
Main focus of research:
Classic and genetic risk factors and biomarkers for cardiovascular diseases.
Approximate number of probands:
285.000 currently in the MORGAM database.
Types and number of biosamples available:
DNA, serum, plasma, urine;
ca. 3,5 million samples available at the participating centres.
Chronic Disease Epidemiology and Prevention Unit
National Institute for Health and Welfare (THL)
Contact for BBMRI-LPC:
Kari Kuulasmaa, see above
Further information and participating centers:
Information on participating cohorts, cohort sizes and characteristics: MORGAM e-publication "Description of MORGAM Cohorts".