Maastricht University Cohort - Cohorts of The Netherlands
Short description of background, aims, hosting institution:
In 1986, the Netherlands Cohort Study (NLCS) on diet and cancer was started. The cohort of 55-69 year old men (48.2%) and women (51.8%) originates from 204 computerized municipal population registries throughout the country. At baseline, participants completed a self-administered questionnaire on diet and potential confounding variables. In addition, about 75% of the participants provided toenail clippings. Cancer follow-up consists of annual record linkage to a pathology registry and to cancer registries. A case-cohort approach is applied, in which detailed follow-up information of a random subcohort (n = 5000) provides an estimate of the person-time experience of the cohort. Exposure data of the subcohort are combined with those of incident cancer cases, yielding exposure-specific incidence rate ratios. The intraindividual variation in determinants was estimated by 5 annually repeated measurements (n = 250) within the subcohort. Toenail clippings are used as source of DNA for cohort members; in the past they have also been used for selenium status. In addition, tumor material of incident cases is collected on a large scale in the NLCS.
Main focus of research:
Cancers (and molecular subtypes).
Approximate number of probands:
Types and number of biosamples available:
Toenails (DNA): ca. 90,000, buccal swabs: ca. 2,000, tumor blocks from cancer patients: ca. 1,000.
Piet van den Brandt
Maastricht University, Department of Epidemiology
Maastricht 6200 MD
Contact for BBMRI-LPC:
Piet van den Brandt, see above.
Piet A. van den Brandt, R. Alexandra Goldbohm et al: A large-scale prospective cohort study on diet and cancer in the Netherlands. Journal of Clinical Epidemiology, Volume 43, Issue 3, 1990, pp 285-295, ISSN 0895-4356.