Rotterdam Study - Cohorts of The Netherlands
Short description of background, aims, hosting institution:
The Rotterdam Study is a single center prospective cohort study that started in 1990 in Ommoord, a suburb of Rotterdam, among men and women aged 55 and over. The main objective of the Rotterdam Study is to investigate the prevalence and incidence of and risk factors for chronic diseases in the elderly.
Baseline measurements were obtained between 1990 and 1993 and consisted of a home interview asking for current health status, medical history, smoking habits, socio-economic status, current drug use (ATC-classification), use of medical facilities, dietary habits, alcohol consumption and physical activity. During two visits at the research center for clinical examinations several measurements were performed: cognitive function, indicators for Parkinson's disease, Dual-Energy X-ray Absorptiometry (bone mineral density), X-rays of hands, thoraco-lumbar spine, hips and knees, an extensive ophthalmologic examination, ultrasound assessment of cardiac dimensions, diameter of the abdominal aorta, carotid arterial wall thickness and plaques thickness, a computerized ECG, blood pressure readings, anthropometry and limited physical examination. Additionally, a venous blood sample was taken and a glucose tolerance test was performed.
All participants were subsequently examined in follow-up examination rounds every 2-3 years.
Morbidity and mortality is registered through general practitioners practices and hospital discharge records.
The Rotterdam Study is hosted by the Department of Epidemiology, Erasmus Medical Centre Rotterdam
Main focus of research: cardiovascular, neurological, loco motor and ophthalmologic diseases in the elderly.
Approximate number of probands: 15,000.
Types and number of biosamples available: blood, urine; ca. 120,000 samples.
Department of Epidemiology
Erasmus Medical Centre
PO Box 2040
3000 CA Rotterdam
Dr. Molewaterplein 50
3015 GE Rotterdam
Office secretariat Epidemiology: Ee 21-73
tel: +31 10 70 43488 / 43391 / 43489
fax: +31 10 70 44657
Contact for BBMRI-LPC:
University Medical Center Groningen
P.O. Box 30001
Groningen, Groningen, 9700 RB
Further information: see The Rotterdam Study website